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Jan 2018 - Oct 2021

Delineating how PI3K/PTEN oncogenic signalling contributes to prostate cancer

Student

Manisha Dass

Location

Cardiff

Funding Amount

£13,500

Supervisor

Dr Helen Pearson

Cancer Type

Prostate

Funding Type

PhD

Status

Complete

Research Type

Biology

This PhD is part funded through the Knowledge and Economy Skills Scholarship 2 Programme which you can find out more about here

Study:

The project aimed to identify novel therapies for prostate cancer driven by abnormal activation of the PI3K signalling pathway which promotes metabolism, proliferation, cell survival and growth in response to extracellular signals. Loss of a tumour suppressor gene called PTEN within this pathway generates a more aggressive prostate cancer than prostate cancer caused by the main facilitator of this pathway, therefore the project sought to identify the molecular mechanisms behind these differences to better understand how the two tumour types can be treated in the clinic.

Results:

By performing highly in-depth analysis of genetic profiles taken from prostate tumours that do not possess PTEN, the team identified significantly increased expression of genes involved in an additional signalling pathway responsible for processes such as the immune response, cell survival and inflammation. Therapeutic targeting of this pathway was explored in a range of 2D and 3D cell and tissue culture models, which suggested potential benefit for targeting this pathway in prostate cancer patients.

Impact:

If pre-clinical data shows promise for advancing into human prostate cancer clinical trials, this project will have found a therapy that will specifically help patients that have lost the tumour suppressor PTEN. As loss of PTEN is a frequently observed driver of prostate cancer, these findings have the potential to help a large proportion of patients that may have otherwise undergone alternative treatments that are not specific enough to fully target the molecular mechanisms facilitating tumour growth.

Next Steps:

The student has now gone on to develop novel platforms for sequencing genetic material that will assist hospitals/companies fight genetic disease and cancer. The research group at Cardiff University continues to work on projects closely linked to this PhD.

The KESS2 collaboration with Tenovus Cancer Care has given me more out of a PhD than I would have ever expected. It has enabled me to communicate my research to a range of audiences across Wales and in turn, gain skills that are not solely laboratory focused. My experience with Tenovus has been wonderful and I am very appreciative of the funding that has been awarded for this project. It truly has been an honour to work alongside Tenovus who are incredibly passionate about making a difference for cancer patients and their families.

Manisha Dass

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